BIRC5 and acute lymphoblastic leukemia: A role of p53 in the cellular response to survivin depletion may not come too much as a surprise, given the close interplay of survivin and p53.1, 35 For example, survivin depletion caused p53 activation in neuroblastoma cells not only in our study but also in a previous study.9 In ALL cells, survivin depletion-induced toxicity could be rescued by p53.36