Previous studies reported STAT3 nucleates a transcriptional repressive complex composed of DNMT1 and HDAC1 in SHP-1 promoter site, thus leading to the silencing of SHP-1 in cancers.27 Therefore, we explored the effect of pectolinarigenin on STAT3/DNMT1/HDAC1 complex formation in 143B nuclear lysates. Here, HDAC1 is linked to cancer.