Macrophages and certain tumor cells die in response to single treatment with Smac mimetics through NF-κB- and autocrine TNFα>TNF-R1-dependent cell death.48, 50, 51 Intriguingly, Smac mimetics showed only weak killing potential per se on neutrophils and only when all three IAPs were targeted. Here, NFKB1 is linked to neoplasm.