Macrophages and certain tumor cells die in response to single treatment with Smac mimetics through NF-κB- and autocrine TNFα>TNF-R1-dependent cell death.48, 50, 51 Intriguingly, Smac mimetics showed only weak killing potential per se on neutrophils and only when all three IAPs were targeted. The gene discussed is TNFRSF1A; the disease is neoplasm.