XAB2 is also essential for early mouse embryogenesis, because knockdown of XAB2 in mice has been shown to lead to embryonic lethality.12 It was previously demonstrated that XAB2 could interact with retinoic acid receptor A and histone deacetylase 3, and XAB2 deficiency increased all-trans retinoic acid (ATRA)-induced cellular differentiation in ATRA-sensitive and -resistant cancer cells. Here, XAB2 is linked to cancer.