Estrogen deficiency has been considered the primary mechanism of osteoporosis in both women and men, but epidemiological evidence in humans and recent mechanistic studies in rodents indicate that aging and the associated increase in ROS are proximal culprits.34, 35 To explain the age-related increase of miR-218 and reduction of Rictor in osteoblasts, we further explored the potential role of ROS in this process. Here, RICTOR is linked to osteoporosis.