CASP9 and neoplasm: This study indicated that the combination of baicalin and baicalein had a synergistic effect on inducing apoptosis in tumor cells by activating caspase-3 and caspase-9, reducing Bcl-2 expression, and increasing Bax or p53 expression via the extracellular signal-regulated kinase (ERK)/p38 MAPK pathway [31].