We recently demonstrated that the glycomimetic compound Polyman26, a hexavalent dendrimer composed of two trivalent dendrons connected by a rod-like spacer, completely inhibits HIV-1 Bal Trans infection of CD4 T cells at a concentration of 10 μM and results in an inhibition of infection >98% at a concentration of 0.5 μM with an IC50 of 24 nM23. Here, CD4 is linked to infection.