PIK3CA mutation types identified in the present study were similar to Chaft et al.’s study, which enrolled 1125 lung adenocarcinoma patients for the detection of four PIK3CA mutation types (c.1624G > A (p.E542K), c.1633G > A (p.E545K), c.3140A > G (p.H1047R), and c.3140A > T (p.H1047L)) by mass spectrometry–based nucleic acid assay16. This evidence concerns the gene PIK3CA and lung adenocarcinoma.