CTNS and cystinosis: Since heterozygous cystinosis patients, who all lacked functional cystinosin due to the 57-kb deletion on one allele and another CTNS mutation on the other allele, did not exhibit any difference in capsaicin responses or heat sensitivity compared to healthy subjects, we can exclude that reduced capsaicin sensitivity represents a general effect of the disease cystinosis (or of the drugs taken to manage the disease and/or kidney transplant) on sensory processes or vascular responses.