In silico protein-protein interaction analysis revealed a network with a clustering coefficient significantly higher than expected by chance (p-value = 0.0022) that interestingly depicts relationships of SAMD11 to several retinal dystrophy-associated genes such as the photoreceptor-specific transcription factor Cone-Rod homeobox (CRX) (Supplementary Figure S1). This evidence concerns the gene CRX and inherited retinal dystrophy.