Increase in colon cancer risk with increasing levels of IGF‐1 (OR of 2.30 and 2.66 for third and fourth quartile, respectively)Rectal cancer risk was inversely related to levels of IGF‐1 (OR of 0.33 and 0.33 for third and fourth quartile, respectively). The gene discussed is IGF1; the disease is malignant colon neoplasm.