IGF1 and neoplasm: 25 that glioma cells also had high expression of IL‐1β. Immunological homeostasis maintains an absent or low expression of IL‐1β, which could only be upregulated by stimulation of inflammatory signals 26, 27. Large‐dose IL‐1β promotes expression of IGF/HGF, MMPs, MCAM, VEGF, and NLRP3, and played a role in tumor angiogenesis, cell invasion, and dispersion 25, 28, 29, 30.