This was associated with the fact that HBOT enhanced PO2 in tumor tissues and thus leaded to low expression of HIF‐1α, TNF‐α, IL‐1β, VEGF, MMP9, and NF‐κB. Therefore, hyperbaric oxygen therapy might be a potentially effective therapeutic option and might improve the prognosis for patients with glioma. The gene discussed is MMP9; the disease is central nervous system cancer.