Regorafenib is an oral multikinase inhibitor that blocks the activity of multiple protein kinases, including those involved in the regulation of tumor angiogenesis (VEGFR1, 2, and 3, and TIE‐2), oncogenesis (KIT, RET, RAF‐1, BRAF, and BRAFV600E), and the tumor microenvironment (PDGFR and FGFR) 1, 2, 3. The gene discussed is TIE1; the disease is neoplasm.