S100A12 and atherosclerosis: Consequently, dysregulation in S100A12 secretion is found in many pathological situations like atherosclerosis, diabetes, chronic inflammatory disorders, and cancer (Kosaki et al. 2004; Salama et al. 2008; Mori et al. 2009; Pietzsch and Hoppmann 2009; Donato et al. 2013).