Two other reports have recently proposed the application of a 4-gene transcriptional signature comprising GBP1, ID3, P2RY14, and IFITM3 (17), and a separate 3-gene transcriptional signature comprising GBP5, DUSP3, and KLF2 (18), as the basis of potential diagnostic tests for active TB. This evidence concerns the gene DUSP3 and tuberculosis.