Using SVM models trained on half the AdjuVIT active TB and Fever cohort cases and tested on the second half of data blinded to the training, we showed that each of these alternative signatures performed substantially better than BATF2 in discriminating between active TB and other infectious diseases in the Fever cohort, achieving ROC AUCs of 0.82 to 0.83 (Figure 6A). The gene discussed is BATF2; the disease is tuberculosis.