For example, in a study of 103 newly diagnosed patients with acute myeloid leukemia (AML), Rybka and colleagues found that the mRNA expression of TLR2 and TLR4 was significantly higher in the bone marrow of patients with myelomonocytic and monoblastic acute leukemia compared to those with other types of AML. Here, TLR4 is linked to acute myeloid leukemia.