MYD88 and diffuse large B-cell lymphoma: The dependence of oncogenic MyD88 on TLRs has also been suggested in activated B-cell (ABC) diffuse large B-cell lymphoma (DLBCL), where both the depletion of a number of proteins necessary for TLR7 and TLR9 trafficking and signaling, including UNC93B1, CD14, and PRAT4A, and pharmacologic inhibitors of these TLRs led to cell death in vitro (70).