The dependence of oncogenic MyD88 on TLRs has also been suggested in activated B-cell (ABC) diffuse large B-cell lymphoma (DLBCL), where both the depletion of a number of proteins necessary for TLR7 and TLR9 trafficking and signaling, including UNC93B1, CD14, and PRAT4A, and pharmacologic inhibitors of these TLRs led to cell death in vitro (70). This evidence concerns the gene CNPY3 and diffuse large B-cell lymphoma.