INSR and posterior cortical atrophy: We then exposed PCa cells to different levels of glucose to mimic normal and hyperglycemic conditions: we observed that when DU145 cells were exposed to normal, physiologic levels of glucose (5 mM) they predominantly expressed the IR-A isoform but when exposed to hyperglycemic levels of glucose (25 mM) the IR-B isoform was the main isoform expressed.