Infection with an antimonite-resistant Leishmania strain upregulated multidrug resistance-associated protein 1 (MRP1) and permeability glycoprotein (P-glycoprotein) in host cells, leading to the inhibition of intracellular drug accumulation by reducing antimonite influx (Figure 3) (Mukherjee et al., 2007; Mandal et al., 2009). Here, ABCC1 is linked to infection.