Despite an increasing knowledge about the genetic and signaling abnormalities involved in the RCC carcinogenesis, such as VHL, PBRM1, SETD2, and BAP1, no biomarkers are currently available thus there are no molecular factors which may guide the clinicians in choosing the therapeutic strategy (Brugarolas, 2014; D'Aniello et al., 2014; Cavaliere et al., 2015). This evidence concerns the gene VHL and renal cell carcinoma.