MAPT and Insulin resistance: There has been some proposed causes for cognitive impairments in diabetic patients, including microvascular disease, advanced protein glycation, mitochondrial dysfunction and oxidative stress, insulin resistance and the abnormal deposition of Aβ and tau phosphorylation, brain blood barrier dysfunction, impaired neruogenesis and inflammation problems (Exalto et al., 2012; Umegaki, 2014).