MSTN and muscular dystrophy: In the past few years, blockage of the MSTN/ACVR2B pathway as a therapeutic strategy for muscular dystrophies, muscle wasting, and cachexia has been investigated in multiple clinical trials (NCT01099761, NCT01519349, NCT01423110, NCT01669174, NCT01601600, and NCT01433263) [National Institutes of Health (NIH), Bethesda, MD, USA; https://clinicaltrials.gov].