Diabetes other than T2DEvidence of renal disease (serum creatinine>1.5 mg/mL)Evidence of liver disease (AST/ALT>3 times of normal)Pregnant or lactating women and subjects intending pregnancyParticipation in any other clinical trial within the last 30 daysHistory of any hemoglobinopathy that may affect determination of glycosylated hemoglobinTreatment with oral anti-diabetic agents (other than metformin or sulfonylurea) during the 12 weeks before baselineHistory of intolerance or hypersensitivity to sulfonylurea or metformin or fenugreek seed extract. The gene discussed is GPT; the disease is kidney disorder.