In addition, in a rat model of experimental stroke, DMF significantly decreased infarction volume and improved neurobehavioral deficits 14 days after middle cerebral artery occlusion (MCAO), concomitant with the induction of Nrf2 and HO-1 and the reduction in immune cell infiltration and harmful inflammatory cytokines in the plasma and brain. The gene discussed is HMOX1; the disease is stroke disorder.