Although some authors have remarked a potential role of CD80 in certain glomerulopathies, such as IgA nephropathy, primary focal and segmental glomerulonephritis and crescentic glomerulopathies [20, 21, 33, 34], others have recently seriously questioned these findings, particularly in minimal change disease and primary focal and segmental glomerulosclerosis [35]. This evidence concerns the gene CD80 and glomerular disorder.