In human gliomas, one of the most common genetic aberrations is the homozygous deletion of CDKN2A. Because CDKN2A encodes both p14/ARF and p16/INK4A, the deletion of CDKN2A results in the disruption of both the p53 and Rb1 pathways [4]. This evidence concerns the gene CDKN2A and glioma.