To date studies of TGF-β1 C-509T and T869C polymorphisms effects on risks of cancers such as hepatocellular carcinoma [40, 41], breast cancer [22, 42], gastric cancer [43, 44], and esophageal squamous cell carcinoma (ESCC) [45, 46] have also yielded somewhat conflicting results. This evidence concerns the gene TGFB1 and esophageal squamous cell carcinoma.