HNF1B has three main regions of risk association (Figure 1) in which the four most significant risk variants for these two cancer types lie: rs11649743 in linkage block 7, rs4430796 and rs7501939 (all prostate) are in strong linkage disequilibrium in region 8 (r2 = 0.764) (Table 1), with the most significant SNP for serous invasive ovarian cancer risk rs757210 immediately adjacent. The gene discussed is HNF1B; the disease is cancer.