HNF1B and Familial prostate cancer: Over-expression of HNF1B corresponded with a marked reduction in proliferation in PC3 and DU145 prostate cancer cells compared to empty vector (EV) controls (p < 0.0001, Figure 4A-i); no effect was observed in normal prostate PNT2a model (p = 0.6629; Figure 4A-ii), while viability was unaffected in all cell lines (Figures 4A-iii and 4A-iv) HNF1B over-expression also led to a decrease in the rate of cell migration in prostate cancer models (p < 0.0001) (Figure 4B-i), but HNF1B levels had no effect on cell migration in PNT2a cells (p = 0.7771; Figure 4B-ii).