Finally, to assess the phenotypic effects of HNF1B in the context of ovarian cancer, we over-expressed HNF1B in IOSE4 ovarian epithelial cells and tested typical tumor phenotypes: we observed significant effects on proliferation (Figure 5A), migration (5B) and invasiveness (Figure 5C) in IOSE4-HNF1B cells compared to IOSE4-EV control cells. Here, HNF1B is linked to ovarian carcinoma.