In addition, PC risk SNP rs11649743-G was associated with significantly lower levels of HNF1B promoter methylation in tumor tissues in British samples (p = 0.0296; Figure 3B-i), while promoter region risk allele rs3760511-G associated with reduced HNF1B promoter methylation in the Danish cohort of 21 pairs of laser-capture micro-dissected (LCM) tumor and normal and adjacent-normal samples (p = 0.0283; Figure 3B-ii). This evidence concerns the gene HNF1B and pachyonychia congenita.