Using rat basophilic leukemia RBL-2H3 cells where the P2Y14 receptor is endogenously expressed [11], we demonstrate that TMPS does not induce degranulation in opposition to UDPG, UMPS, CMPS, AMPS, and a selective P2Y14 receptor agonist, namely MRS 2690 (diphosphoric acid 1-α-D-glucopyranosyl ester 2-[(4'-methylthio)uridin-5''-yl] ester). This evidence concerns the gene P2RY14 and acute basophilic leukemia.