In this regard, alterations in proteins of the differentiated and cornified layers of the skin (such as cornifelin, corneodesmosin, transglutaminase 1, alox12B, ABCA12 etc.), has been associated with various cutaneous pathologies in human, such as inflammatory diseases, i.e. psoriasis, eczema, dermatitis and ichthyosis [28–30]. Here, TGM1 is linked to skin disorder.