EDN1 and Familial prostate cancer: Moreover, we observed increased expression of genes that are also overexpressed in different types of cancer (SPINK7; BEX2, EDN1, CEACAM; PDPN; EREG; FBN1; CTHRC1; SLC6A14; IL1β etc), among them we found upregulation of genes involved in the development of skin carcinomas (LCN2; TNFRSF19 etc.); head and neck squamous cell carcinomas (CRTC1, CCNA1 (CYCLIN A1); EREG; NEFL; LCE3D), and prostate cancer (PDPN (podoplanin), LCN2).