Our results are interesting in light of a recent case study of a 21 year old female with a 5 year history of CTCL, primary cutaneous small/medium, pleomorphic CD4+ T cell lymphoma, who achieved a 13 month complete remission through oral treatment with doxycycline monohydrate at a dose of 200mg per day [53]. Here, CD4 is linked to primary cutaneous T-cell non-Hodgkin lymphoma.