DICER1 and nonpapillary renal cell carcinoma: The multivariate COX regression analysis further showed that positive Dicer expression was an independent favorable prognostic factor for 5-year overall survival and disease specific survival of ccRCC patients after adjusting with classical factors, such as age, tumor size and TNM stage (HR = 0.709, 95% CI = 0.525 to 0.957, P = 0.025 for 5-year overall survival; HR = 0.655, 95% CI = 0.479 to 0.896, P = 0.008 for disease-free survival; Table 3).