Clinical studies show that specific SNPs in the gene encoding ifnar1 are associated with resistance to cerebral malaria [50], and case-control studies in Angolian children and neuro-malaria patients in Thailand support that type I IFN responses are either associated with the development of cerebral malaria [51] or precede the induction of IFN-γ expression and severe disease [20]. The gene discussed is IFNG; the disease is malaria.