Because α-IFNAR treatment significantly reduced the number of IL-10+IFN-γ+Plasmodium infection-induced Tr1 cells and serum IFN-γ and IL-10 levels, we hypothesized that combinatorial IL-10R signaling blockade and IFN-γ neutralization would phenocopy α-IFNAR treatment, resulting in increased Tfh accumulation, improved humoral immunity, and enhanced parasite control during experimental malaria. This evidence concerns the gene IL10 and malaria.