Correlation analyses between ploidy and SAFs have positive and significant r values (%SA-βgal: r = 0.89, p = 0.0004; %Senescent-like: r = 0.91, p < 0.0001; %CDKN2A: r = 0.97, p < 0.0001; %CDKN1A: r = 0.87, p = 0.0005), indicating increased expression of senescent markers as W-CIN levels increase (Fig. 4e–h and Supplementary Table S3). This evidence concerns the gene CDKN1A and cervical squamous intraepithelial neoplasia.