Correlation analyses between ploidy and DNA DSBs have positive and significant r values (% γH2AX: r = 0.71, p = 0.013 and %53BP1: r = 0.73, p = 0.01) (Fig. 5g, Supplementary Table S3 and Fig. S4b), suggesting higher incidence of DSBs as W-CIN levels increases. The gene discussed is TP53BP1; the disease is cervical squamous intraepithelial neoplasia.