In fact, some of the W-CIN-induced SASP components overlap with those from DNA damage-induced senescence (CXCL8, CSF2, CCL2, IL6)48, 49, while others are distinct, suggesting that DDR may be only one of the facets of W-CIN-induced senescence. Here, CXCL8 is linked to cervical squamous intraepithelial neoplasia.