Altogether, we may not anticipate that overexpression of CaV1.2e21+22 channels in the heart will induce cardiac hypertrophy, rather CaV1.2e21+22 channels could dominant-negatively disturb particularly the caveolae-localized CaV1.2 channels and activate the calcineurin/NFAT in response to hypertrophic stresses. Here, CACNA1C is linked to cardiac hypertrophy.