CACNA1C and aortic stenosis: Nevertheless, it is tempting to speculate that, in the patients suffering aortic stenosis or severe hypertension, CaV1.2e21+22 channels may reemerge in the heart and disturb the expression and activity of CaV1.2 channels, in particular of those channels localized in the caveolae, and consequently lead to cardiac hypertrophy.