NFKB1 and breast cancer: Most recent findings demonstrated that cycloartane triterpenoids isolated from C. foetida could inhibit Raf/MEK/ERK signaling pathway and Akt phosphorylation in breast cancer MCF-7 cells11, as well as suppress TNFα-induced IKKα/β and IKBα phosphorylation, and nuclear factor (NF)-κB downstream target gene expression in triple-negative breast cancer cells12.