A hypothetical function for LRRK2 in the regulation of macroautophagy, and in general in vesicle homeostasis, is compelling considering that the macroautophagy/lysosomal system has an increasingly appreciated link to the etiology of PD29, while it has long been considered a central player in the pathogenesis of Crohn’s, leprosy and cancer. This evidence concerns the gene LRRK2 and cancer.