Although the activation of NLRP3 inflammasome under HG is unknown in human monocytes, its role in various cell types, including cardiomyocytes, adipose tissue and pancreatic islet cells has been proposed8, 9, 10, which linked the pathogenesis of T2DM and its complication to chronic inflammation7, 41. This evidence concerns the gene NLRP3 and type 2 diabetes mellitus.