The CHC model combining hepatic miR-122, hepatic miR-224, platelet count, ALT and albumin allowed the identification of CHC patients with F3-F4 from those with F1-F2 with better diagnostic performances than APRI and FIB-4 (AUC = 0.93, 95% CI = 0.87–0.99, Se = 0.89, Sp = 0.84, NPV = 0.97) (Table 4). The gene discussed is GPT; the disease is cryohydrocytosis.