CHC patients with F1-F2 had lower ALT (p = 0.0002), AST (p < 0.0001), ALP (p < 0.0001), GGT (p < 0.0001), total bilirubin (p = 0.011), glycemia, (p = 0.0003) and cholesterol (p < 0.0001) than CHC patients with F3-F4 (Table 1). The gene discussed is GPT; the disease is cryohydrocytosis.