LAMTOR1 and Sepsis: In addition to the investigation on intracellular molecular mechanism of Lamtor1 in M2 polarization, we showed the role of Lamtor1 in polarization of M2MΦs at the healing stage of aseptic peritonitis model, and also showed that loss of Lamtor1 in macrophages led to the marked hypercytokinemia and high mortality in a mouse sepsis model.