CD38 expression was the factor significantly differentiating CLL patients, and 20/84 (23.8 %) analyzed miRNAs were expressed lower in the CD38+ group: let-7a-5p, miR-7c, let-7d-5p, let-7e-5p, let-7f-5p, miR-101-3p, miR-130b-3p, miR-146b-5p, miR-15a-5p, miR-182-5p, miR-18a-5p, miR-199a-5p, miR-19b-3p, miR-210-3p, miR-28b-3p, miR-29a-3p, miR-29c-3p, miR-331-3p, miR-335-5p, and miR-34a-5p (Table 4). The gene discussed is CD38; the disease is B-cell chronic lymphocytic leukemia.