This, coupled with recent publications, suggesting a role for the RAS in cancer growth (18), with components of the RAS: ACE, ATIIR1, and ATIIR2, being demonstrated in areas of cancer (25), led to the notion of RAS playing a role in tumor angiogenesis and tumor cell proliferation (25), both being determinants of tumor growth and metastasis. The gene discussed is ACE; the disease is cancer.