SOX2 and neoplasm: We have recently demonstrated the presence, within MDBMSCC, of an EMA+/SOX2+/SALL4+/OCT4+/pSTAT3+/NANOG+ CSC subpopulation within the tumor nests; an EMA−/SOX2+/OCT4+/pSTAT3+/NANOG+ CSC subpopulation within the peri-tumor stroma; and an EMA−/CD34+/SOX2+/OCT4+/pSTAT3+/NANOG+ CSC subpopulation localized to the endothelium of the microvessels within the peri-tumoral stroma (16).