We have recently demonstrated the presence, within moderately differentiated buccal mucosal squamous cell carcinoma (MDBMSCC), of an EMA+/SOX2+/SALL4+/OCT4+/pSTAT3+/NANOG+ CSC subpopulation within the tumor nests; as well as two separate peri-tumoral stromal populations one expressing EMA−/SOX2+/OCT4+/pSTAT3+/NANOG+ and another expressing EMA−/CD34+/SOX2+/OCT4+/pSTAT3+/NANOG+ localized to the endothelium of the microvessels (16). This evidence concerns the gene POU5F1 and neoplasm.