IC50 values ranged from 10.13 μg/mL (towards CEM/ADR5000 cells) to 72.01 μg/mL (on resistant colon carcinoma HCT116 (p53−/−) cells) for PSR, from 14.97 μg/mL (on CEM/ADR5000 cells) to 65.68 μg/mL (against HCT116 (p53−/−) cells) for PSB, from 18.21 μg/mL (against CEM/ADR5000 cells) to 65.21 μg/mL (on HCT116 (p5+/+) cells) for PSL and from 0.11 μg/mL (towards CCRF–CEM cells) to 108 μg/mL (against CEM/ADR5000 cells) for doxorubicin in the 8 other cancer cell lines studied. The gene discussed is TP53; the disease is colon carcinoma.