We have demonstrated in a nutritional mouse model of NAFLD and in primary hepatocyte cell culture that LCN2 is directly linked to the intracellular formation and accumulation of hepatic lipid droplet accumulation partly via regulation of the lipid droplet protein Perilipin 5 (Asimakopoulou et al., 2014). This evidence concerns the gene LCN2 and metabolic dysfunction-associated steatotic liver disease.