It will be exciting to follow up if LCN2 will be added to the list of biomarkers suitable in HCC diagnosis and which superior insights in HCC development or progression will arise from LCN2 measurements that are not already disclosed by other serum markers such as α-fetoprotein (AFP), M39, M65, soluble CD163, or others that are already in use as tissue- or serum-associated HCC biomarkers (Waidmann et al., 2013; Morris et al., 2014; Chauhan and Lahiri, 2016). Here, CD163 is linked to hepatocellular carcinoma.