DISS protects human neuroblastoma cells (SH-SY5Y) from Glu- or H2O2-induced damage, and DISS-mediated regulation of BDNF expression is associated with CREB-mediated transcription of BDNF and upstream activation of ERK1/2 and CaMKII (Hu et al., 2014). The gene discussed is CREB1; the disease is neuroblastoma.