EGFR and neoplasm: From this perspective, ErbB/HER-derived peptides including those derived from activating mutations, such as the EGFRvIII variant with a mutation in the extracellular domain of the receptor, have the potential to stimulate an anti-tumor immune response innately or via vaccination (Li and Wong, 2008; Nedergaard et al., 2012; Paff et al., 2014; Schneble et al., 2014).