Antigen-mediated immunotherapy: HPPS was formulated with a fusion peptide consisting of α-helical apoA-I-mimetic peptide and an antigen peptide against ovalbumin (expressed by E.G7 lymphoma cells) to generate a lymphoma nanovaccine, which demonstrated the most potent in vivo therapeutic effects of the four multi-homing strategies described herein. The gene discussed is APOA1; the disease is lymphoma.