Importantly, although we suggest that downregulation of c-FLIP is important in the response to Nutlin-3 in AR-dependent cells, we have not yet obtained a global assessment of other androgen-regulated genes in this setting, which might shed light on alternative pro-survival mechanisms that could be altered in response to Nutlin-3, or explored as potential future prostate cancer treatments. This evidence concerns the gene CFLAR and prostate carcinoma.