Breeding c-myc-3’RR mice in a genetic background (α1-knock-in mice) [29] where IgA replaced IgM (IgA inducing stronger tonic BCR signaling than IgM) led to the generation of more differentiated CD138+ and less proliferative B-cell lymphomas [30]. The gene discussed is MYC; the disease is B-cell non-Hodgkin lymphoma.