In addition to confirmation of the strong effect of TP53 mutations in APC-WT cancers on CNA- and BP-scores (p =1.5E-5 and p = 0.002, respectively) (Figure 5C–5D), it also revealed that APC mutations in TP53-WT cancers were associated with increased CNA- and BP-scores compared to TP53-APC double WT cancers (p = 2.1E-5 and p = 0.01, respectively) (Figure 5C–5D). Here, TP53 is linked to cancer.