After 6 and 12 months of infection of iqgap1+/- mice, both H. pylori strains and H. felis induced significant inflammation in the gastric mucosa and sub-mucosa associated with an increase in mucosal height (Figure 1), an atrophy with the replacement of parietal and chief cells by mucous-producing cells defining a mucinous metaplasia (Figure 1). This evidence concerns the gene IQGAP1 and infection.