IQGAP1 and infection: In order to confirm this point, groups of iqgap1-/- mice, iqgap1+/- mice and WT littermates, were infected or not (control) with only H. felis to determine the consequences of invalidating one or both iqgap1 alleles on the development of gastric inflammation and pre-neoplastic lesions 6 months post-infection (PI).