In the present study, aged iqgap1+/- mice showed no more basal inflammation or alterations of the gastric mucosa than their WT littermates, and infection with the cagA-positive HPARE H. pylori strain induced more inflammation and pre-neoplastic lesions in iqgap1+/- mice than in WT littermates after 12 months. Here, IQGAP1 is linked to infection.